SP-0225: Studying normal tissue damage using small animal high-precision irradiators

Precision Radiotherapy for Small Animal Research

Preclinical research using well characterized small animal models has provided tremendous benefits to medical research, enabling low cost, large scale trials with high statistical significance of observed effects. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those models available for the development and evaluation of novel radiation therapies. SARRP demonstrates ...

Soft Tissue Studies In Small Animal Radiography

Computer- and robot-assisted stereotaxy for high-precision small animal brain exploration.

This contribution introduces a computer- and robot-assisted framework for stereotactic neurosurgery on small animals. Two major elements of this framework are presented in detail: a robotic stereotactic assistant and the software framework for placement of probes into the brain. The latter integrates modules for registration, insertion control, and preoperative path planning. Two options for pa...

A high precision MR-compatible positioning system for focused ultrasound experiments in small animal models

Introduction: Magnetic resonance guided focused ultrasound (MRgFUS) therapy is a non-invasive technique for targeted blood-brain barrier disruption, site-specific delivery of pharmaceuticals, and controlled heating and coagulation of tissues [1, 2]. However, the translation of this technology into clinical practice still requires extensive testing in preclinical rodent models, yet the small siz...

The Effect of Full Crown Preparation on Normal and Inflamed Pulp Tissue: An Animal Study

Introduction: Full crown preparation may have adverse effects on pulp tissue. In this study, the effect of full-crown preparation on intact versus inflamed pulp tissue was studied. Methods: Fifteen healthy mature cats were randomly selected for this study. The study was performed on four canine teeth of each cat. Cats were anesthetized and then radiographs were taken from the canine teeth. Clas...